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In recent years, ketamine and ketamine-derived treatments have emerged as a promising option for people with treatment-resistant depression (TRD) and suicidal thoughts. Research shows that ketamine can reduce symptoms—and even suicidal ideation—within hours to days for many patients when used carefully in a medical setting. [1,3]
At Arthritis & Osteoporosis Center of Northern Virginia, our addiction medicine team offers ketamine treatment in a way that is evidence-based, safety-focused, and mindful of addiction risks, so you can explore this option with support, structure, and compassionate care.
What is ketamine treatment for severe depression?
Ketamine is an anesthetic that has been used safely for decades. At much lower doses, it acts as a fast-acting antidepressant for people with severe or treatment-resistant depression [1].
In mental health care, ketamine is administered in sub-anesthetic doses, typically by IV infusion or as an FDA-approved nasal spray. Patients remain awake but monitored, and many describe the experience as mildly dissociative or dreamlike [1].
Because ketamine carries misuse potential, it should always be administered under medical supervision—something our addiction medicine team is uniquely qualified to manage [7].
What is ketamine treatment for severe depression?
Ketamine is an anesthetic that has been used safely for decades. At much lower doses, it acts as a fast-acting antidepressant for people with severe or treatment-resistant depression [1].
In mental health care, ketamine is administered in sub-anesthetic doses, typically by IV infusion or as an FDA-approved nasal spray. Patients remain awake but monitored, and many describe the experience as mildly dissociative or dreamlike [1].
Because ketamine carries misuse potential, it should always be administered under medical supervision—something our addiction medicine team is uniquely qualified to manage [7].
What is ketamine treatment for severe depression?
Ketamine is an anesthetic that has been used safely for decades. At much lower doses, it acts as a fast-acting antidepressant for people with severe or treatment-resistant depression [1].
In mental health care, ketamine is administered in sub-anesthetic doses, typically by IV infusion or as an FDA-approved nasal spray. Patients remain awake but monitored, and many describe the experience as mildly dissociative or dreamlike [1].
Because ketamine carries misuse potential, it should always be administered under medical supervision—something our addiction medicine team is uniquely qualified to manage [7].
What is ketamine treatment for severe depression?
Ketamine is an anesthetic that has been used safely for decades. At much lower doses, it acts as a fast-acting antidepressant for people with severe or treatment-resistant depression [1].
In mental health care, ketamine is administered in sub-anesthetic doses, typically by IV infusion or as an FDA-approved nasal spray. Patients remain awake but monitored, and many describe the experience as mildly dissociative or dreamlike [1].
Because ketamine carries misuse potential, it should always be administered under medical supervision—something our addiction medicine team is uniquely qualified to manage [7].
What is ketamine treatment for severe depression?
Ketamine is an anesthetic that has been used safely for decades. At much lower doses, it acts as a fast-acting antidepressant for people with severe or treatment-resistant depression [1].
In mental health care, ketamine is administered in sub-anesthetic doses, typically by IV infusion or as an FDA-approved nasal spray. Patients remain awake but monitored, and many describe the experience as mildly dissociative or dreamlike [1].
Because ketamine carries misuse potential, it should always be administered under medical supervision—something our addiction medicine team is uniquely qualified to manage [7].
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References:
1. Yavi M, Zohar J. Ketamine treatment for depression: a review. Front Psychiatry. 2022.
2. Zanos P, et al. Mechanisms of ketamine action as an antidepressant. Pharmacol Rev. 2018.
3. Zolghadriha A, et al. Rapid and sustained antidepressant effects of intravenous ketamine in treatment-resistant depression. BMC Psychiatry. 2024.
4. Aleksandrova LR, et al. Antidepressant effects of ketamine and AMPA receptor involvement. Front Neurosci. 2017.
5. Lullau APM, et al. Antidepressant mechanisms of ketamine: a review. Front Neurosci. 2023.
6. Feder A, et al. Therapy-enhanced outcomes following ketamine treatment. Front Psychiatry.
7. Beerten SG, et al. Ketamine misuse: an update for primary care. Br J Gen Pract. 2023.
8. Anderson DJ, et al. Ketamine-induced cystitis: a comprehensive review. Curr Urol Rep. 2022.
9. FDA. Spravato (esketamine) prescribing information. Updated guidance.
10. Anand A, et al. Ketamine vs. ECT for nonpsychotic treatment-resistant major depression (ELEKT-D trial). N Engl J Med. 2023.
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